I have taken Desoxyn for just over four years now, and I am prescribed it for ADD as well as to help with my refractory depression. I had previously been on Adderall, Ritalin, Focalin, Concerta, and Dexedrine/Dextrostat. All of them either stopped working well, or got to the point where the dosage was so high that the side effects over-powered the desired effects (particularly with Adderall and Concerta, which happened at a total of 120mg/day and 144mg/day, respectively). Just before I switched to Desoxyn, I was taking 2x15mg Dexedrine XR and 4x10mg Dexedrine IR tablets a day, for a total of 70mg daily. This was getting to be too much for me, so I made the switch. What impressed me at first was that at just 20mg/day, I was getting the same ADD-helping effects from the Desoxyn that it took 70mg of Dexedrine to achieve, but I felt NO SIDE EFFECTS. The Desoxyn is smooth, lacking the ups-and-downs of the time-release stimulants, of which Adderall and Concerta were the worst IMO. Not only that, but unlike the IR Adderall or Dexedrine which only lasted 4-5hrs thus requiring the XR/ER be taken as well, the Desoxyn 5mg IR tablets work fully for a solid 8 hours, with a very smooth and light comedown afterwards unlike the "crash" from the regular amphetamines. Pros: High potency = lower dose, fewer side effects, long duration of action without requiring any "extended release" system, less interrupting to sleep, appetite suppression is slightly more mild Cons: Expensive (120tab = $640), rarity makes it difficult to find a pharmacy that carries it so it will likely have to be special-ordered, twice-day dosing may cause sleep interruptions for some people, "stigma" associated with m,-amphetamine, majority of MD/PharmD have no idea what Desoxyn is Overall, it has been, for me, the best solution to my ADD. In five years, I have never even had to have one dose adjustment!Read More Read Less