In hindsight, all was pretty tolerable until the second week of 1.0mg. After 14 days of feeling increasingly worse (extreme and sudden depression and crippling anxiety, weakness to the point I can barely walk across the house, fatigue, massive brain fog, confusion, dizzy, cold and chills with no fever, rash on arms, swelling in neck, headache, eye pain, blurry vision, jacked up blood pressure) I went to the ER. All sorts of abnormal labs for kidney function, electrolytes, metaboloc acidosis and messed up red blood counts. Prior to that dose, I was doing great, exercising daily, sticking to my lifestyle changes and happy with the results. Now I'm weak and unable to exercise, work, concentrate, feeling unmotivated, tired, moody, and anxious. It feels like I'm literally dying and there's nothing that helps. It's everything I can do to force myself to eat and drink a little bit. This med doesn't help that much to justify feeling like absolute hell, mentally and physically for weeks after stopping it. I see that many people experience the same gigantic kick in the face at the 1.0 to 1.7 mg dose . I wish there was an antidote, I would pay anything to end this torture. I'll do this my dang self once I can muster the strength to move, think clearly, and get out of this quick, hard hitting depression. Sorry brain, sorry kidneys, bye-bye sanity. Read More Read Less