User Reviews for same

I use 200 mg twice daily as part of a low dose combo regimen, with first dose upon awakening/30 min before breakfast. Other supplements I take at the same time are 500 mg tyrosine and 250 CDP-citicoline. This maximizes effectiveness and minimizes side effects - for me at least! Also take an extra strength fish oil cap once daily for both mood and lipid effects. It took about 2 months to feel a lifting of my dysthmia with this regimen.

200mg worked well for a few days but didn't have the same results after 2 weeks. I'm waiting to see if it is unrelated before I bump up to 400mg. Vit D suppl had the same amount of feeling better. I'm working on finding a good mix to get better. I don't want to be on Zoloft or any prescription anymore but I'm not there yet.

It helps keep the pain under control. I can tell when I don't take it. But I can't take more than 400mg a day because more puts me in a manic state. also problem with runs but once body gets used to it this problem clears up.

I had gas pockets in the intestine after taking SAM-E, which has become very painful and warranted trip to the hospital. I became extremely hostile and nearly lost my job. The constipation was the last straw. I saw a commercial advertising SAM-E and found that it was available without a prescription, and purchased the supplemnt. Worse decision I made!