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4.2 Overall Rating

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Most voted positive review

267 People found this comment helpful

I first discovered SAMe ( I think from a radio program in NYC) about 12 years ago when insurance ran out and I could no longer afford antidepressants. The AD's were also no longer performing very well. Coincidentally (I thought) I was suffering from the symptoms of Fibromialgia....very badly. Thousands of dollars and 2.5 years of varying fibro treatments ...guess what finally knocked it out. A...

Most voted negative review

34 People found this comment helpful

i DID NOT KNOW ABOUT THIS TILL TODAY.

Shared reviews and ratings

chumpy | Age: 35-44 | On supplement for 1 to 6 months |
8/4/2010
Condition: Other
Overall rating 4.0
Effectiveness
Ease of Use
Satisfaction

Started Sam-e month ago for ADHD. Its has also cured my migrine headaches that I had for years too. Im amazed and feel great! The dosing was an issue at first since they come in 200 and 400mg. Used 1/4 of the 200mg a day. Very happy..

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Age: 55-64 |
7/25/2010
Condition: Other
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

Within 24 hours of taken 200 mg, I noticed a difference upon getting out of bed the following morning with less stiffness. I have not been taking Sam-e for about a month and the inflammation in my knees has been reduced to the point where I have almost no discomfort. I stopped taking Aleve and now only take one 81 mg. aspirin on the suggestion of my doctor but that is not for osteoarthritis.

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Age: 45-54 | On supplement for 6 months to less than 1 year |
6/13/2010
Condition: Other
Overall rating 4.3
Effectiveness
Ease of Use
Satisfaction

Works well, however the side effect of cramps is hard to live with.

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vstardiva | Age: 45-54 | On supplement for 2 to less than 5 years |
5/16/2010
Condition: Other
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

I have taken Sam-e for years. I am awaiting surgery date for a full hip replacement. The D. prescribed an anti-inflammatory but after reading the side effects it wasn't something I wanted to stay on. After reading book written on Sam-e I found that I needed to increase my dosage. I now take 400mg 3-4x a day and it is THE ONLY THING I TAKE FOR PAIN! The higher dose has been MAGIC for me. I am bone on bone but, I sleep well, feel refreshed, and no longer feel weepy! No one beleives this manages my pain...even my doctor is surprised...Love it! I highly recommend this product, just trying a higher dose made all the difference for me.Read More Read Less

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Patti A. | Age: 45-54 | On supplement for 10 years or more |
5/3/2010
Condition: Fibromyalgia
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

If you are concerned or hesitant about SAM-e, I say don't be. I was diagnosed with Fibromyalgia and Chronic Fatigue Syndrome 11 years ago. My doctor suggested a new drug in the U.S. called SAM-e that had been in use in Europe for many years with great success. I tried it and it worked wonderfully! I've been taking it ever since. Sometimes when I am feeling better I stop taking it, but if I start to feel the effects again I get some more. I should probably just stay on it. :-) This really is a great supplement. A little expensive, but how can you put a price on how you feel everyday????Read More Read Less

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Carol | Age: 45-54 | On supplement for less than 1 month |
4/26/2010
Condition: Fibromyalgia
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

I have a very bad case of fibromyalgia. Traditional medicine did not work or even help. I finally went to an accupunturist and he recommended Sam-e. He also said to take Omega 3 fish oil, four a day. My life has completely changed. This is like a miracle. I take 400 mg of Sam-e daily, but have taken one more a day occasionally, if I start going downhill a bit. I recommend this to everyone with pain. Give it a couple of weeks, start at 400mg, but you can take 2 or 3 a day if needed. You will be so happy you did....some days I could barely move, I was in so much pain...everywhere. But I am getting much better. It is worth every dime you pay for it. Buy it, your quality of life is certainly worth it. Read More Read Less

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Carol | Age: 45-54 | On supplement for less than 1 month |
4/26/2010
Condition: Fibromyalgia
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

I have a very bad case of fibromyalgia. Traditional medicine did not work or even help. I finally went to an accupunturist and he recommended Sam-e. He also said to take Omega 3 fish oil, four a day. My life has completely changed. This is like a miracle. I take 400 mg of Sam-e daily, but have taken one more a day occasionally, if I start going downhill a bit. I recommend this to everyone with pain. Give it a couple of weeks, start at 400mg, but you can take 2 or 3 a day if needed. You will be so happy you did....some days I could barely move, I was in so much pain...everywhere. But I am getting much better. It is worth every dime you pay for it. Buy it, your quality of life is certainly worth it. Read More Read Less

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Amy | Age: 25-34 | On supplement for 1 to 6 months |
3/19/2010
Condition: Other
Overall rating 4.7
Effectiveness
Ease of Use
Satisfaction

Before I tried this, I was sleeping 12 to 15 hours a day, crabby, sad, and had no energy. After taking this supplement for a few weeks, I am sleeping better and waking refreshed after just 7-8 hours with no alarm set! My energy is greatly improved, and I don't know if it is the pill or the energy boost, but my mood is improved as well. I am taking 400 mg daily.

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Age: 25-34 | On supplement for 6 months to less than 1 year |
3/15/2010
Condition: Other
Overall rating 3.3
Effectiveness
Ease of Use
Satisfaction

good

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Age: 25-34 | On supplement for 6 months to less than 1 year |
3/12/2010
Condition: Other
Overall rating 3.3
Effectiveness
Ease of Use
Satisfaction

good

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murphysullivan | Age: 65-74 | On supplement for 1 to 6 months |
3/2/2010
Condition: Other
Overall rating 4.0
Effectiveness
Ease of Use
Satisfaction
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Age: 45-54 | On supplement for 1 to 6 months |
2/11/2010
Condition: Other
Overall rating 4.3
Effectiveness
Ease of Use
Satisfaction

I have a minimal headache but divide the 200mg tablet into fourths to prevent insomnia

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kristinela | Age: 35-44 | On supplement for 1 to less than 2 years |
2/10/2010
Condition: Other
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

I use 200 mg once per day of Nature's Sunshine Products Sam-E. I've been using for over one year now for mood swings. Effects were noticible within a week. I have had no side effects at all as I did with prescirption medication like Prozac. I was surpised to see so many side effects noted in these reviews. I can't say it takes away all my pain but my emotional sense of well-being is greatly imporved!

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MM | Age: 55-64 | On supplement for 1 to 6 months |
2/3/2010
Condition: Other
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

I was prescribed an anti-depressant and didn't want to go on one again. My doctor asked if I had ever tried Sam-e. After taking 400 mg once a day for a couple of weeks, I noticed I was feeling like my old self again. Slight constipation and some dry mouth in the morning, but I can live with that since I feel so much better. I recently increased my magnesium and the constipation is improving. I also have fibromyalgia and have been able to start exercising again. Over all I just feel like I have regained some of my zest for life and I am so grateful.Read More Read Less

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Getsomesame | Age: 25-34 | On supplement for 1 to 6 months |
1/22/2010
Condition: Other
Overall rating 4.7
Effectiveness
Ease of Use
Satisfaction

I was given this by my boyfriend whose mother is an herbalist. It worked wonders for my mood to the point where after a month of using it I could stop and feel better even without it. But I have a recurring problem with depression. It would last for months but eventually would come back. One problem I have found is that I am prone to UTI's and each time I take SAMe I get one. Could be coincidence. I did start taking SAMe again this week and I have another UTI but I also drink a lot of soda. I am going to cut out the soda for a few days and continue the SAMe to see if it persists. Also, before taking I slept horrible and my back and muscles were hurting something awful and that has disappeared. It was the first time I had had muscle pain like that\I take the Natures Sunshine brand. Its the best.Read More Read Less

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Original Barbie | Age: 45-54 | On supplement for less than 1 month |
1/18/2010
Condition: Other
Overall rating 4.3
Effectiveness
Ease of Use
Satisfaction

I read about this treatment last year and as with any "pill", I was hesitant. I believe my problems are actually four-fold: 1) depression 2) obesity 3) fibromyalgia 4) osteoarthritis. I've been taking this for 3 weeks now and feel better than I've felt in years! No joint or muscle pain has improved by 95%, I was sleeping at least 14 hours per 24 hour period and I'm now sleeping just 7-8 hours, I feel refreshed and actually joined a gym last week and am making an effort to eat healthier. Is it the Sam-e or my mind. At this point, who cares! I have had some minor stomach pain and diarrhea. I am monitoring that.Read More Read Less

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Pam | Age: 45-54 | On supplement for 1 to 6 months |
1/9/2010
Condition: Fibromyalgia
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

You must be careful of the type of SAMe you purchase, I tried several brands and had weight gain, bloating, indigestion, constipation until I purchased Doctor's Best 400 mg for symptoms of SAD (seasonal affective disorder) with fibromyalgia which decreased within 48 hrs. and the intestinal symptoms ceased. It doesn't hurt to increase fiber as IBS and Fibromyalgia go together. I have no more side effects and you can purchase online inexpensively. This has helped with Vit D 4000 mg. Previous winters in Colorado have left me crying daily and bedridden. I would still love to winter in Costa Rica, but now I can manage. Praise God!Read More Read Less

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nibor | Age: 35-44 | On supplement for less than 1 month |
1/3/2010
Condition: Other
Overall rating 3.3
Effectiveness
Ease of Use
Satisfaction

post partum depression-got better.

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HappyAgain | Age: 35-44 | On supplement for 1 to 6 months |
12/15/2009
Condition: Other
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

I was desperate to find a non-prescription or natural alternative for depression, as I am currently without health insurance. In my search I found SAMe. It is by prescription only in some European countries, so I thought I would try it if the European doctors are prescribing it. I started with the dose of 400mg and have been taking it in the morning before starting my day. I read that taking later in the day may cause insomnia, so why not try first thing in the morning. I noticed after about a week, I woke up refreshed and rested, where as normally I was dragging out of bed and through the day. It has increased my sense of well-being and my depression and moodiness seem to have decreased. I was having difficulty making it through the work day due to feeling emotionally over-sensitive and just full of dread being there. I truly feel SAMe has saved my job, because my clients were starting to react to my mood behavior. I have not had any constipation problems or gas as others have stated in earlier comments. I am very glad to have found SAMe and will continue to take it. I may lower my dosage to 200mg in the future, but I've only been taking it for about 2months so I will wait to decrease after the holidays.Read More Read Less

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blue27 | Age: 25-34 | On supplement for less than 1 month |
12/14/2009
Condition: Other
Overall rating 2.3
Effectiveness
Ease of Use
Satisfaction

I wanted to use this as a treatment for depression. Taking 400mg once a day and only a week into use, it's given me constipation, mild headaches, insomnia, gas, and dry mouth. I'm willing to finish all of the 36 doses to cure or alleviate some the depression if there are no more added sideffects.

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