i have ostioarthritis in both knees,well in all my joints,i have taken 2 of the 3 required shots.i will not go get the third.was not told of any side effects at my doc.office.i go to a sports medicen doc.he works on our football team here.was told that i needed to not do anything for 24 hrs. after shot.so i took off work the next day.i got my 2nd shot on a thursday,took off thursday,and worked the late shift on friday.was doing ok,but went to work on sunday and my leg was on fire.very sever leg cramps in my calf and behind my knee.went to the target beside us,got some ben gay,didn't work,thank god i had took my cold packs with me to work,so i went to the break room and froze my whole leg.took a vicodin,helped some.i've had a knee replacement on my right knee and am bone on bone in my left,like i was with my right knee.i will not get the third shot,will go back to the cortizone shots that i have been doing for years.that was the worst leg cramps i have ever had,and am still sore this morning.took a flexeril last night before bed,at least that let me sleep.i was not told of any side effects at all,and like others the brochure does not mention any either.i almost went to the emergancy room last night,thats how bad the pain was!scared the heck out of me!think hard about this drug,it might work for you,and then it might not,but if you do take it,ask about side effects,if they tell you there are none,tell them you have read reviews about it and there are side effects.a left knee replacement is in store for me,i know that,but was trying hard to put it off for a little bit,as i just had the right one done in january of 2010..no third shot for me,i'll go back to the cortizone,it work great for years for me.Read More Read Less