User Reviews for zoledronic acid intravenous

I had my first infusion of Zoledronic Acid over 5 years ago. I experienced hair loss, tinnitus, muscle aches and pain, fatigue, blurry vision, glaucoma and chronic diarrhea. The infusion had helped my osteopenia. The diarrhea, tinnitus, hair loss and vision problems still continue. In February 2023, my Rheumatologist convinced me to have another infusion. That was the worst mistake I have ever made. Six months later, the chronic diarrhea has worsened. I cannot leave the house. The muscle aches and pains are so bad that it is difficult to get out of bed in the morning. I was at the point where I could walk a mile a day, and the diarrhea was not as frequent. I do not care about osteoporosis when I cannot even move or leave the house because of diarrhea several times a day. I will never have a zoledronic acid infusion again. The terrible side effects will probably remain with me the rest of my life. I am 76 years old.Read More Read Less

I have experienced every reaction in the list I am between 6 and 7months and still suffering. I would not recommend this product, no way to gage the reactions and no way to stop them. Its long term and no way out of the the side effects!!!!! Hate what is going on in my body and mind. I have never felt this messed up.

If your healthcare provider recommends this drug, run! SIDE EFFECTS ARE HORRIBLE. I have been on this for a month and I have to say that I think their sample set during the clinical trial must have been skewed. Go to any website where actual people can leave reviews and you will see that loads of people have "rare" side effects. I have neck pain, jaw pain, bone pain in my left foot that is so bad I have to walk with crutches, dehydration, eye pain, and food tastes like metal. I was perfectly healthy apart from osteoporosis diagnosis in both hips. No fractures, no osteoporosis in spine. Now I am in constant pain and can't stand or walk. They should take this off the market.Read More Read Less

This infusion caused year-long muscle pain in my thigh & lower leg that kept me up at night. I will never take it again!!

Experiencing breathing difficulties elevated diaphram neck pain started 3 weeks after 1st infusion. What treatment is recommended and how long will this continue

4 months after getting a shot I developed a leg tremor ... It is rapidly getting worse, and I don't know what to do to reverse the symptoms? Can anyone help me please??

Six weeks out, I have paralyzed diaphragm pushed up against my lungs rendering breathing difficult (panting), exhaustion, difficulty sleeping, pain along the phrenic nerve (left shoulder/neck), brain fog, constipation, shaky, kidney pain, shuffling not walking, etc. Be especially careful if you have pre-existing conditions. Warnings say the effects may be permanent.

This treatment has and still is making my teeth break and crumble even after 18 months after the 5th infusion. I refused to have the final one. My left leg bone below the knee has also bent causing half knock knee on the left side. Cancer consultant say this drug hasn't caused it but I beg to differ. I would lie in bed at night trying to deal with the pain of my muscles spasming and twisting my left leg bone and knee was unbearable and lasted for hours. This drug shouldn't be used especially on people who have other problems especially neutral tube defects Imo. I feel I've been used as a guinea pig to see what the outcome of using this drug would be. Read More Read Less

I don't know if it has worked for me, I only know that after having the infusion, that night my body was in intense pain and I developed a bad kidney infection. I was given antibiotics to fight the infection. It's been over two weeks and I'm still NOT well. I have spent most of that time in bed. I am weak, tired and with no energy. Before the infusion I had gone for my annual physical, and I was fine. Now I wonder if I'll ever get my strength back. I don't recommend it!

I had this treatment done yesterday. I was told that it would keep the calcium in my bones, so I thought it would be a good thing. Last night was awful. I thought I was dying. My chest hurt, I thought I was having a heart attack! I had acid reflux all night. I had fever, chills. My whole body hurt. I had nausea and vomiting. Was going to the bathroom about every thirty minutes. My body felt like it weighed a ton! I had to struggle to make it to the bathroom. I would not have chosen to have this treatment if I had known how sick it would make me! I was told to take Ibuprofen, what a joke! Now I know! I will not be having a second or a third treatment! The side effects are scary!Read More Read Less

I only had it three days ago so have no idea if it works. What I can say is it’s the worst pain I’ve ever had. I feel as if someone is inside my skeleton paring at it with a knife. I can hardly stand and walking nearly impossible. And the doctors say take paracetamol - are they kidding? I keep being told that it’s rare to experience a reaction like this so it’s a relief to find this website and hear of similar tales.

I was diagnostified osteoporosis primaria 3months ago, after serial pathological rib fractures. I recieved my first dose of zoledronic acid 18hours ago, and now feel like every fracture is broken again. This is horror

Since having been given this zolodronic bone treatment I have bad the continuing worst bone pain imaginable. My knees and ankles constantly give me pain, the knees and ankles are the worst as I can't even weight bare on them. My left knee has changed position and my right knee grinds and crunches when I try and move. Walking has become a nightmare and before having being prescribed this I got around easily without pain in my knees. I have teeth that have crumbled and one is shattered but I refuse to have it removed in fear of developing jaw necrosis. The zolodronic infusions were stopped for about 18 months during the Covid pandemic and the full course wasnt given after as they never gave me the last infusion. I'm now on the waiting list for knee surgery, which I dread, as I don't know what this drug had done too my bones and if they'll heal properly. Has anyone else had these experiences?Read More Read Less

Dat two had very painful joints the had a very painful left eye which turned out to be inflammation behind the eye. Suffered from severe neck and head pain. Day 6 have severe neck and head pain also severe hand pain. Wake up during the night with neck and head pain, so tired. What pain what pain will I experience on day seven. Was told I am suffering from rare side effects. The only person I received great care from was the eye Consultant, now my eye is much improved. I also suffer from dizziness. Doctors don’t seem to care, nor do the infusion team. Feel very alone with this condition. I have been told I cannot have this treatment again because of side effects. Thea drug seems to attack every part of the body and I wonder when will it end!!Read More Read Less

After both ankles sustained compound fractures simultaneously 5 years ago, I began treatment for osteoporosis at age 71. I did 1 year of bi-monthly Prolia injections; 1 year of Evenity monthly injections, all with no immediate or long-term side effects. Now at age 75, my Dr. recommended the once a year Reclast. My bone density is not due until November '22. I have been walking well, drove myself to the infusion center and drove myself home with no problems. But less than 12 hours later, I awoke with severe hip, thigh, buttocks, leg and ankle pain, ALL ON THE RIGHT SIDE OF MY BODY! I could barely roll over to get out of bed! It was hard to distinguish joint pain from muscle pain from bone pain! This is finishing up day 5 post-infusion and I have to use a walker to get around my home, and have to sit to shower as I can't stand alone as the pain is so intense. Luckily my home is already handicapped accessible in bathrooms, doorways, and halls, so I can maneuver a wheel chair if it, God forbid, becomes necessary. There are no words to "cleanly" express how angry, disappointed and frustrated I am...I trusted a good doctor with my bone health, and I am now certain that I will be worse off than before this injection....NEVER AGAIN!Read More Read Less

I don't have osteo yet but I have muscular dystrophy so my doc wanted to be proactive. I was scared to have the infusion but did my research and decided pros outweighed the odds. I had no initial side effects post infusion - I was very happy. But a month or two later, I've got horrible joint pain and discomfort making it harder to walk and fall asleep. There is a constant ache in my lower back and legs. I also feel weaker. I can't prove its attributable to Reclast, but it is the most likely culprit. The aches in my joints are making me miserable. Read More Read Less

I am a Breast cancer survivor, finished chemo 12/1/22 and had bilateral mastectomy with immediate reconstruction in February…. Now on immunotherapy for 6 months. As part of my last phase of treatment… Was given My 1st dose of Zolendronic acid infusion on 15/6/22… within 8hrs of having it, I developed widespread bone, joints and muscle pains beyond a pain I have ever experienced before with high temperatures which would not settle for days despite iv antibiotics and paracetamol. I was in hospital for 5days on slow release morphine and oromorph for breakthrough pain and by day 5 I needed strong anti inflammatory meds as most of my joints where swollen including finger and toe ones. I could not walk… reduced to using a Zimmer frame to get myself to the toilet…& sitting on the toilet or any seat was torture I am 2 weeks in today, the pains are much less and I have reduced my pain meds to just paracetamol… but the exhaustion i feel is so depressing especially that it took a lot to get myself back up fit from chemo and surgery for breast cancer. Before this infusion I was walking 8000 steps 3 times a week, doing house chaos, even restarted driving short distances and for once in 11months I felt like I was getting my life and confidence back…. It’s now very frustrating to go 5 steps backwards only to restart rebuilding again! Seeing my oncologist next Monday to discuss way forward re: this treatment… I am not sure I want it anymore… I ve been told they can swap it to another.. I am still not sure I will take it regardless! It’s vile ! Read More Read Less

PLEASE STAY AWAY FROM ZOLENDRONIC ACID INFUSION: The medication is lethal! I am writing this review on a hospital bed, with diagnosis of Pancreatic Ca! My lab works were all normal few days prior to ZOL infussion including liver function tests, so I was cleared to receive ZOL infusion. On 18th May 2022, I received ZOL infusion in the morning, this was my first dose and the first time. 16 hours later, I began to pee dark yellow urine, had high fever through the night, and suffered increase level of pain. 2 days after the infussion I started noticing yellowness on my skin and eyes. I thought it was just one adverse reaction, and was still able to carry out my normal day-today tasks. One week later I continued to pee yellow, and my poop had changed to chalky color. I knew something terrible is going on. I rushed to an ER, where they did blood tests and abdominal scan and they told me there was pancreatic sessions that has metastated to the liver! the Radiologist stated "you need to act really fast ..." I have been through MRI, CT Scan, and a failed ERCP! because there's big blockage of the common bile ducts! I am still at the hospital, not sure if I'll ever survive long enough to write this BOLDLY! You have this review, now you know there are risks they are not telling people about! I read other reviews in which people are saying ZOL causes cancer ... but no one has come openly to say if or not they got cancer after the treatment. BUT NOW YOU KNOW! My main reason for taking time to write this review is to alert everyone of the lethality and danger of this medication! ZOL is killing, and I hope the manufacturers would read this review and put an end to this dangerous drug - ZOLENDRONIC ACID INFUSSIONRead More Read Less

It's early stages for me, but I had a back reaction with flu like symptoms, sickness and aching mainly in the torso area, I'm still suffering with the aches a week later, I had this injection for Bone marrow edema, I really hope this doesn't continue as the pain can be quite severe.

In a couple of weeks I'm going in for my third infusion in three years (I get mine at my local VA hospital). I've had no side effects from the infusions. So far, it has improved my bone density for which I'm extremely grateful because my mother's hip spontaneously broke due to her severe osteoporosis. As for me, I'm all in!