User Reviews for Semglee U-100 Insulin subcutaneous

I was switched by my insurance from Lantus to Semglee. I saw no changes regarding the insulin but the pens were defective. I had a box and there were 4 pens where they didn't inject insulin. I took a pen to pharmacy and they told me to get in touch with manufacturer to get replacement. I had to talk to numerous call center reps to file a complaint and they were less concerned with replacing and more concerned with me filing out proper forms for a complaint. Absolutely, worst customer service ever received!!Read More Read Less

this poison put me in the hospital for 9.5 hours . Flushing , trouble breathing, things were spinning , lights steaming , over all felt bad all over , and only took part of a dose, stay away from this stuff !!!!

After 50 years as a Type 1 using NPH it was time for a change. My evening insulin wasn't lasting nearly long enough. Then there were the peaks and valleys. I switched to Semglee and it was a total game changer. Completely steady activity for 24 hours. Used with the Libre 2 things become much easier to manage. As far as all of the complaints of ineffectiveness and weight gain, I have not had those issues. I'm very active and fit. I hike, I bike, and run. Something every day. Cannot speak for others but it works well for me. The biggest change for me making the switch was that because it is so long-lasting and steady I became much more sensitive to my fast acting insulin. prior to Semglee there were times my fast acting had to make up the waning activity of my basal insulin. Now i'm very sensitive to the fast acting and I love it.Read More Read Less

Reading through the reviews, I finally feel like I’m not losing my mind. Always very controlled on Lantus for many years. Insurance company also switched me to Semglee. I also have experienced unexplained weight gain (exercise almost daily and watch what I eat). Blood sugar readings are a roller coaster. Has caused mental anguish which in turn affects my relationships. Feeling extremely frustrated and defeated fighting to switch back to Lantus.

My a1c was 7.1 when I started taking semglee in 2020. It is now 8.8 with no changes in my diet. I also have to inject 50 units instead of the 30 i was on with Lantus. My insurance changed it and my doctor and pharmacist (walgreens) had not even heard of Semglee at that time. It had been approved 6 months after filing. It doesn't work.

I’m on Semglee and I’ve put on 2 stone in weight. I’m breathless and when I injected it’s pain ful . They don’t care my tummy is very swollen.

I am likely a type 1 that was misdiagnosed as a type 2 years ago (TL;DR I had a suspected (suspected by my Endo) autoimmune episode at 22 yo that destroyed 60-70% of my beta cells.) I had just enough insulin to not go DKA but to not have good control either. MD didn’t do peptide/antibody because there was “no way I was Type1 because I was 26 so bring on Type 2 meds that never really worked right…of course that was totally lack of willpower said my MDs. I ran 23 years on a mix of every med under the sun and occasional long-acting insulin. I have had dawn phenomena the whole time which most of my MDs told me was impossible and a figment of my imagination. The Dexcom finally showed it was real and they admitted I might be a type 1.5. They supercharged my poor betas with meds and they did the best they could. My beta cells (what was left of them) finally gave up the ghost about 6 weeks ago, according to tests, and I ended up in DKA. I responded AWESOMELY to 30 units of IV insulin and m/l 15 units of sliding scale while in the ICU for 6 days. I was taken off the drip 4 days in and put on 24 units of Lantus (14 AM, 10 PM) with Humalog for sliding scale 4Xs daily. My control was nice and solid (130 averages). I was sent home with 1.5 pens of Lantus and used for the first 15 days home. Control wasn’t hard and my AGP (Dexcom G6) over 14 days was 6.2!! Express Scripts wouldn’t cover Lantus (I hate our profit driven healthcare system)…I was told Semglee was biosimilar and a 1:1 replacement. Not even close. My control is a nightmare on 65 units (35 AM 30PM). It takes 30-40U, over several injections, of Humalog to keep me averaging 160ish. It’s almost like the Semglee isn’t there at all. Thank God my Omnipod5 training is TOMORROW and I take my last garbage shot of Semglee at 7pm tonight. I respond great to fast acting and will be solely on Humalog from here on out. I have reached out to my PCP and Endo and advocated for any other patients on this garbage. Express Scripts will allow Lantus IF your MD will go to bat and say it’s not working. Prior Authorization is possible. Advocate for yourself and fight for your health! Get back on Lantus or get on a pump (that’s not hard either…get with a diabetes pharmacist (mine is at my local med center) and they will help you navigate Express Scripts.). Be persistent and ask your MD to truly advocate for you. You deserve a med that works! Good Luck to you all. Maybe someday big pharma and the insurance companies will care about the patient first. I keep praying for that day to come…JoeRead More Read Less

Semglee is ineffective and is not designed to help patients. My husband has been on this insulin since last year and he has gained at least 20 pounds in his mid section, his glucose levels are on a roller coaster and this is causing him much mental anguish. Our insurance company has refused to pay for Lantus and so we are left with this substandard product!

ever since they switched Lantus to this semglee i have gained almost 15 pounds, I am swollen and retaining water and it snot helping at all. I don't even know what to do since my insurance wont cover lantus anymore

If I could give less stars I would. This has been the worst long lasting insulin ive ever had, I have had 4 pens actually break on me, some examples are: plunger in the quick pen some how detached and will not Push insulin, the dial on the pen to set how many units is locked on two pens, and lastly on my fourth pen just one pen wont shoot any insulin, I tried new needles and plunger is fine so no idea. The insulin also gives me erratic high to lows no consistencies. All in all lantus is 100x better an wish express scripts and semglee actually cared for the voices of it clientsRead More Read Less

Semglee is not an effective substitute for Lantus. I am a 46+ year well controlled (6.4 A1C) Type 1 diabetic largely due to Lantus as my long acting insulin. It has been decades since I have experienced a low blood sugar to the extent I did recently since taking Semglee due to my insurance refusing to allow my continued use of Lantus. Semglee provides sharp, erratic highs and lows where Lantus provided a smooth, consistent long acting blood sugar control. How an insurance company can derail the health a patient has counted on and ignore the orders of the doctor who has been treating them for years successfully I might add I will never understand. It should be criminal!!!Read More Read Less

Express made me change from Lantau to Semglee. It has been awful. I used 35 units once daily of Lantaus. I now use 60 units of Semglee and my sugars are uncontrollable and I am swollen and have other issues and have gained over 23 lb. I hate this insulin.

I have been taking Semglee for 7 months. I feel like I'm getting water as it doesn't give me good results like Lantus but insurance company will not cover Lantus so I'm stuck with this junk

Semglee does not work for me. I was on Lantus before this. My insurance would not continue paying for Lantus so had to switch to semglee. Not happy. Will see if can go back to Lantus or another one.

Less effective as compared to previous basilar insulin. Given the same diet and exercise regimen, blood sugar is higher, requiring an increase in dosage.

Been working on eating whole foods and staying away from processed food for over 2 years. 3 years ago my A1C reached 11.?? My last reading this year prior to Semglee was a 7.2 . I was on Lantus and Novolog and working towards getting off insulin. My nightly dose was down to 10 units from dosages as high as 50 units. I has a fasting reading this morning of 436 whereas I was averaging between 60 to 100 fasting. I hate insurance companies and big pharma. This happens to me every few years.

I do NOT think Semglee is as effective as Lantus. I'm about to contact my Dr about this as well. I was completely controlled on Lantus, and have used both as I still had some Lantus left. My glucose levels are FAR more controlled with Lantus. My levels were significantly elevated with Semglee and I can't increase the dose any more without fear of more severe hypoglycemia. I can't pinpoint the "peak" either (which every glargine has - though slight - it has to be accounted for in your control). This is not an equal product. With insurance not covering my Lantus anymore I don't know what to do. Managed care in this country is a business, and cares nothing about anyones "health". It's shameful and a tragedy that I have to fight for my health in this country. I wish the insurance companies would have to turn their bodies in to experimental lab rats as they keep making us do every time they decide not to cover an insulin based on their business and political dealings. I work really hard at being healthy and staying well with Diabetes, and every time I have to try something else due to financial/managed care/political reasons it just undoes all the work we do to stay alive. It should be criminal, because it can kill people. Read More Read Less

This medication SHOULD NOT be prescribed to patients who are doing just fine on Lantus! I experienced weight gain and fluid retention as an otherwise very healthy T1D of 30+ years. I have never had weight issues UNTIL I started this medication for only 3 months. I quickly stopped the Semglee once I realized it was causing my weight gain reaction and bloating. We all know how crucial weight control is to diabetes care. How could this product be approved for daily glucose control when it causes, as a side effect, a symptom which directly impacts diabetics?? DO NOT accept this prescription from your physician or healthcare team if you care about your health as a diabetic. Read More Read Less

This product is not effective at all and since my insurance will not cover Lantus I'm stuck using triple the amount of this crap.

I think this is nothing more than sterile water. Since switching from Lantus my insulin levels are all over the place! With Lantus I KNEW it was working..Makes me wonder..