Dr prescribed Metformin, stated after routine annual blood labs that A1C was up, prediabetic, so add the fact of overweight, kidney stones, gall stones, IBS & with family history of diabetes. Start with 500mg 2x day and build up to 1000 mg 2x day. After 2 weeks, lost 12 lbs, but the gut wrenching pain, gas, nausea, diarrhea, & now constipation. Already was on BP and cholesterol meds. So now can't always tell what is causing it, but can because I was feeling quite well til I started taking this RX. Now I have no appetite, so hard to eat meals, don't drink enough water, due to the gas erupting (both ends), so now getting dehydrated. Trying to eat enough and items that won't cause more gas. It feels like I am in the original Alien movie, just waiting for it to burst thru my tummy, lower left side hurts the worse with cramping. But what gets me is we didn't do more tests prior, cuz I learned that stress can also cause A1C to change, and since I had been under alot having to take care of things as my brother passed away in August and taking care of my mother for 2 months, I wasn't necessarily eating the best for 2 months, not meaning bad foods, just skipping too many meals. So when they state they prescribe this for the better of your health and side effects are suppose to be minimal, I don't agree. Suppose to go on a group bus trip next month 3-4 hour drive, now I am worried about how will I handle these side effects, as there have been times I feel like I wanted to get to the urgent care or ER, as it hurts that bad.Read More Read Less